Job Title
Senior Research Fellow
Department
WMS - Health Sciences
Phone
02476151652
Research Interests
Dr Hee's main research interests are in design and analysis of clinical trials in particular for small population disease. She is also interested in the setting and designing issues of database for individual participant data meta-analysis.
Biography
Siew Wan is a Research Fellow for the Statistics and Epidemiology Unit, Division of Health Sciences, Warwick Medical School. Her first degree was in statistics from the National University of Singapore (NUS) and this was followed by an MSc. also in statistics from NUS. The title of her dissertation was "Exploration of Probes Selection Criteria of Oligonucleotide Array". She was awarded a PhD from The University of Warwick in 2012, thesis titled "Designing a Series of Clinical Trials". She has previously worked as a biostatistician in National Cancer Centre Singapore. Her primary role was to support, assist and advise the design, conduct and analysis of early phase trials and observational studies.
- Underwood, Martin, Achana, Felix, Carnes, Dawn, Eldridge, Sandra, Ellard, David R., Griffiths, Frances, Haywood, Kirstie, Hee, Siew Wan, Higgins, Helen, Mistry, Dipesh, Mistry, Hema, Newton, Sian, Nichols, Vivien, Norman, Chloe, Padfield, Emma, Patel, Shilpa, Petrou, Stavros, Pincus, Tamar, Potter, Rachel, Sandhu, Harbinder et al (Select to open full list), 2023. A supportive self-management program for people with chronic headaches and migraine : a randomized controlled trial and economic evaluation. Neurology, 100 (13) (13), pp. e1339-e1352
- McGregor, Gordon, Powell, Richard, Begg, Brian, Birkett, Stefan T., Nichols, Simon, Ennis, Stuart, McGuire, Scott, Prosser, Jonathon, Fiassam, Olivier, Hee, Siew Wan, Hamborg, Thomas, Banerjee, Prithwish, Hartfiel, Ned, Charles, Joanna M., Edwards, Rhiannon T., Drane, Aimee, Ali, Danish, Osman, Faizel, He, Hejie, Lachlan, Tom et al (Select to open full list), 2023. High-intensity interval training in cardiac rehabilitation : a multi-centre randomized controlled trial. European Journal of Preventive Cardiology, 30 (9), pp. 745-755
- 'McGregor, Gordon, 'Evans, Becky, 'Sandhu, Harbinder, 'Simmonds, Jane, 'Joshi, Shivam, 'Devi, Gita, 'Zhupaj, Albiona, 'Holliday, Nikki, 'Pearce, Gemma, 'Patel, Chloe, 'Hee, Siew Wan, 'Powell, Richard, 'Heine, Peter J., 'Patel, Shilpa, 'Kavi, Lesley, 'Bruce, Julie, 'Hayat, Sajad, 'Lim, Boon, 'Eftekhari, Helen, 'Panikker, Sandeep, 2022. 'Protocol update for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome : the PULSE study. Pilot and Feasibility Studies, 8 (1)
- 'Bradley, Christopher, 'Hee, Siew Wan, 'Andronis, Lazaros, 'Persaud, Krishna, 'Hull, Mark A, 'Todd, John, 'Taylor-Phillips, Sian, 'Smith, Steve, 'Constable, Rachel, 'Waugh, Norman, 'Arasaradnam, Ramesh P., 2022. 'REducing Colonoscopies in patients without significant bowEl DiseasE : the RECEDE Study - protocol for a prospective diagnostic accuracy study. BMJ Open, 12 (3)
- Hee, Siew Wan, Mistry, Dipesh, Friede, Tim, Lamb, Sarah E., Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2021. Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back pain. BMC Musculoskeletal Disorders, 22 (1)
- McGregor, Gordon, Hee, Siew Wan, Eftekhari, Helen, Holliday, Nikki, Pearce, Gemma, Sandhu, Harbinder, Simmonds, Jane, Joshi, Shivam, Kavi, Lesley, Bruce, Julie, Panikker, Sandeep, Lim, Boon, Hayat, Sajad, 2020. Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome : the PULSE study. Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome: the PULSE study, 6
- Patel, Shilpa, Achana, Felix A., Carnes, Dawn, Eldridge, Sandra, Ellard, David R., Griffiths, Frances, Haywood, Kirstie L., Hee, Siew Wan, Mistry, Dipesh, Mistry, Hema, Nichols, Vivien P., Petrou, Stavros, Pincus, Tamar, Potter, Rachel, Sandhu, Harbinder, Stewart, Kimberley, Taylor, Stephanie, Underwood, Martin, Matharu, Manjit, 2020. Usual care and a self-management support programme versus usual care and a relaxation programme for people living with chronic headache disorders : a randomised controlled trial protocol (CHESS). BMJ Open, 10 (4)
- Potter, Rachel, Hee, Siew Wan, Griffiths, Frances, Dodd, Katherine, Hoverd, Eleanor, Underwood, Martin, Matharu, Manjit, 2019. Development and validation of a telephone classification interview for common chronic headache disorders. Journal of Headache and Pain, 20
- White, Kimberley, Potter, Rachel, Patel, Shilpa, Nichols, Vivien P., Haywood, Kirstie L., Hee, Siew Wan, Mistry, Dipesh, Carnes, Dawn, Taylor, Stephanie S. J., Underwood, Martin, Matharu, Manjit S., 2019. Chronic headache education and self-management study (CHESS) - a mixed method feasibility study to inform the design of a randomised controlled trial. BMC Medical Research Methodology, 19
- Hee, Siew Wan, Parsons, Nicholas R., Stallard, Nigel, 2018. Decision-theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta-binomial distribution. Biometrical Journal, 60 (2), pp. 232-245
- Friede, Tim, Posch, Martin, Zohar, Sarah, Alberti, Corinne, Benda, Norbert, Comets, Emmanuelle, Day, Simon, Dmitrienko, Alex, Graf, Alexandra, Günhan, Burak Kürsad, Hee, Siew Wan, Lentz, Frederike, Madan, Jason, Miller, Frank, Ondra, Thomas, Pearce, Michael, Röver, Christian, Toumazi, Artemis, Unkel, Steffen, Ursino, Moreno et al (Select to open full list), 2018. Recent advances in methodology for clinical trials in small populations : the InSPiRe project. Orphanet Journal of Rare Diseases, 13 (1)
- Miller, Frank, Zohar, Sarah, Stallard, Nigel, Madan, Jason, Posch, Martin, Hee, Siew Wan, Pearce , Michael, Vågerö, Mårten, Day, Simon, 2018. Approaches to sample size calculation for clinical trials in rare diseases. Pharmaceutical Statistics, 17 (3), pp. 214-230
- Pearce, Michael, Hee, Siew Wan, Madan, Jason, Posch, Martin, Day, Simon, Miller, Frank, Zohar, Sarah, Stallard, Nigel, 2018. Value of information methods to design a clinical trial in a small population to optimise a health economic utility function. BMC Medical Research Methodology, 18 (1)
- Stallard, Nigel, Miller, Frank, Day, Simon, Hee, Siew Wan, Madan, Jason, Zohar, Sarah, Posch, Martin, 2017. Determination of the optimal sample size for a clinical trial accounting for the population size. Biometrical Journal, 59 (4), pp. 609-625
- Hee, Siew Wan, Willis, Adrian, Tudur Smith, Catrin, Day, Simon, Miller, Frank, Madan, Jason, Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2017. Does the low prevalence affect the sample size of interventional clinical trials of rare diseases? An analysis of data from the aggregate analysis of clinicaltrials.gov. Orphanet Journal of Rare Diseases, 12 (44)
- Hee, Siew Wan, Dritsaki, Melina, Willis, Adrian, Underwood, M. (Martin) M.D., Patel, Shilpa, 2017. Development of a repository of individual participant data from randomized controlled trials of therapists delivered interventions for low back pain. European Journal of Pain, 21 (5), pp. 815-826
- Hee, Siew Wan, Hamborg, Thomas, Day, Simon, Madan, Jason, Miller, F., Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2016. Decision-theoretic designs for small trials and pilot studies : a review. Statistical methods in medical research, 25 (3), pp. 1022-1038
- Patel, Shilpa, Hee, Siew Wan, Mistry, Dipesh, Jordan, Jake, Brown, S., Dritsaki, Melina, Ellard, David R., Friede, Tim, Lamb, S. E., Lord, Joanne, Madan, Jason, Morris, Tom, Stallard, Nigel, Tysall, Colin, Willis, Adrian, Underwood, Martin, 2016. Identifying back pain subgroups : developing and applying approaches using individual patient data collected within clinical trials. Programme Grants for Applied Research, 4 (10)
- Morris, Tom, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2015. Can we convert between outcome measures of disability for chronic low back pain?. Spine, 40 (10), pp. 734-739
- Mistry, Dipesh, Patel, Shilpa, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, 2014. Evaluating the quality of subgroup analyses in randomized controlled trials of therapist-delivered interventions for nonspecific low back pain. Spine, 39 (7), pp. 618-629
- Patel, Shilpa, Ngunjiri, Anne, Hee, Siew Wan, Yang, Yaling, Brown, Sally, Friede, Tim, Griffiths, Frances, Lord, J., Sandhu, Harbinder, Thistlethwaite, Jill, Tysall, Colin, Underwood, Martin, 2014. Primum non nocere : shared informed decision making in low back pain : a pilot cluster randomised trial. BMC Musculoskeletal Disorders, 15
- Ragin, Camille, Obikoya-Malomo, Monisola, Kim, Sungjin, Chen, Zhengjia, Flores-Obando, Rafael, Gibbs, Denise, Koriyama, Chihaya, Aguayo, Francisco, Koshiol, Jill, Caporaso, Neil E., Carpagnano, Giovanna E., Ciotti, Marco, Dosaka-Akita, Hirotoshi, Fukayama, Masashi, Goto, Akiteru, Spandidos, Demetrios A., Gorgoulis, Vassilis, Heideman, Daniëlle A. M., van Boerdonk, Robert A. A., Hiroshima, Kenzo et al (Select to open full list), 2014. HPV-associated lung cancers : an international pooled analysis. Carcinogenesis, 35 (6), pp. 1267-1275
- Mistry, Dipesh, Patel, Shilpa, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, 2014. Evaluating the quality of subgroup analyses in randomized controlled trials of therapist delivered interventions for non-specific low back pain : a systematic review. Spine, 39 (7), pp. 618-629
- Hee, Siew Wan, Stallard, Nigel, 2012. Designing a series of decision-theoretic phase II trials in a small population. Statistics in Medicine, Vol.31 (No.30), pp. 4337-4351
- Toh, Han Chong, Chia, Whay Kuang, Sun, L., Thng, C. H., Soe, Y., Phoon, Y. P., Yap, Swee Peng, Lim, W. T., Tai, W. M., Hee, Siew Wan, Tan, S. H. (Seow-Hwei), Leong, S. S., Tan, E. H., 2011. Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation. Bone Marrow Transplantation, 46 (4), pp. 573-579
- Toh, C. K., Ahmad, B., Soong, R., Chuah, K. L., Tan, S. H., Hee, Siew Wan, Leong, S. S., Tan, E. H., Lim, W. T., 2010. Correlation between epidermal growth factor receptor mutations and expression of female hormone receptors in East-Asian Lung adenocarcinomas. Journal of Thoracic Oncology, 5 (1), pp. 17-22
- Lim, W. T., Tan, E. H., Toh, C. K., Hee, Siew Wan, Leong, S. S., Ang, P. C. S., Wong, N. S., Chowbay, B., 2010. Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors. Annals of Oncology, 21 (2), pp. 382-388
- Leong, S. S., Fong, K. W., Lim, W. T., Toh, C. K., Yap, S. P., Hee, Siew Wan, Tan, E. H., 2010. A phase II trial of induction gemcitabine and vinorelbine followed by concurrent vinorelbine and radiotherapy in locally advanced non-small cell lung cancer. Lung Cancer, 67 (3), pp. 325-329
- Chiang, J., Chan, A., Shih, V., Hee, Siew Wan, Tao, M., Lim, S. T., 2010. A prospective study to evaluate the feasibility and economic benefits of rapid infusion rituximab at an Asian cancer center. International Journal of Hematology, 91 (5), pp. 826-830
- Ang, Mei-Kim, Hee, Siew Wan, Quek, Richard, Yap, Swee Peng, Loong, Susan, Tan, Leonard, Tao, Miriam, Lim, Soon Thye, 2009. Presence of a high-grade component in gastric mucosa-associated lymphoid tissue (MALT) lymphoma is not associated with an adverse prognosis. Annals of Hematology, 88 (5), pp. 417-424
- Shih, Vivianne, Hee, Siew Wan, Chan, Alexandre, 2009. Clinical predictors of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adjuvant doxorubicin and cyclophosphamide. Annals of Pharmacotherapy, 43 (3), pp. 444-452
- Ngeow, J. Y. Y., Quek, R. H. H., Ng, D. C. E., Hee, Siew Wan, Tao, M., Lim, L. C., Tan, Y. H., Lim, S. T., 2009. High SUV uptake on FDG-PET/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG-PET/CT staging in lymphoma. Annals of Oncology, 20 (9), pp. 1543-1547
- Yeo, R., Fong, K. W., Hee, Siew Wan, Chua, E. T., Tan, T., Wee, J., 2009. Brachytherapy boost for T1/T2 nasopharyngeal carcinoma. Head and Neck, 31 (12), pp. 1610-1618
- Tham, Ivan Weng-Keong, Hee, Siew Wan, Yap, Swee Peng, Tuan, Jeffrey Kit-Loong, Wee, Joseph, 2009. Retropharyngeal nodal metastasis related to higher rate of distant metastasis in patients with N0and N1nasopharyngeal cancer. Head & Neck, 31 (4), pp. 468-474
- Tham, Ivan Weng-Keong, Hee, Siew Wan, Yeo, Richard Ming-Chert, Salleh, Patemah Bte, Lee, James, Tan, Terence Wee-Kiat, Fong, Kam Weng, Chua, Eu Tiong, Wee, Joseph Tien-Seng, 2009. Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy - the national cancer centre Singapore experience. International Journal of Radiation Oncology*Biology*Physics, 75 (5), pp. 1481-1486
- Toh, H. C., Wang, W.-W., Chia, W. K., Kvistborg, P., Sun, L., Teo, K., Phoon, Y. P., Soe, Y., Tan, S. H., Hee, Siew Wan, Foo, K. F., Ong, S., Koo, W. H., Zocca, M.-B., Claesson, M. H., 2009. Clinical benefit of allogeneic melanoma cell lysate-pulsed autologous dendritic cell vaccine in MAGE-positive colorectal cancer patients. Clinical Cancer Research, 15 (24), pp. 7726-7736
- Lambert, Caroline, Berlin, Ivan, Lee, Tat-Leang, Hee, Siew Wan, Tan, Audrey S. L., Picard, David, Han, Ji Sheng, 2008. A standardized transcutaneous electric acupoint stimulation for relieving tobacco urges in dependent smokers. Evidence-based Complementary and Alternative Medicine, 2011
- Chia, Whay Kuang, Ong, Simon, Toh, Han Chong, Hee, Siew Wan, Choo, Su Pin, Poon, Donald Y. H., Tay, Miah Hiang, Tan, Chee Kiat, Koo, Wen Hsin, Foo, Kian Fong, 2008. Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma. Annals of the Academy of Medicine, Singapore, 37 (7), pp. 554-558
- Ho, Juliana Teng-Swan, Tan, Puay-Hoon, Hee, Siew Wan, Wong, Jill Su-Lin, 2008. Underestimation of malignancy of atypical ductal hyperplasia diagnosed on 11-gauge stereotactically guided Mammotome breast biopsy : an Asian breast screen experience. The Breast, 17 (4), pp. 401-406
- Yap, S. P., Lim, W. T., Foo, K. F., Hee, Siew Wan, Leong, S. S., Fong, K. W., Eng, P., Hsu, A. A. L., Wee, J. T. S., Agasthian, T., Koong, H. N., Tan, E. H., 2008. Induction concurrent chemoradiotherapy using paclitaxel and carboplatin combination followed by surgery in locoregionally advanced non-small cell lung cancer - Asian experience. Annals of the Academy of Medicine Singapore, 37 (5), pp. 377-382
- Leong, S. S., Wee, J., Rajan, S., Toh, C. K., Lim, W. T., Hee, Siew Wan, Tay, M. H., Poon, D., Tan, E. H., 2008. Triplet combination of gemcitabine, paclitaxel, and carboplatin followed by maintenance 5-fluorouracil and folinic acid in patients with metastatic nasopharyngeal Carcinoma. Cancer, 113 (6), pp. 1332-1337
- Ngo, L., Hee, Siew Wan, Lim, L. C., Tao, M., Quek, R., Yap, S. P., Loong, E. L., Sng, I., Hwan-Cheong, T. L., Ang, M. K., Ngeow, J., Tham, C. K., Tan, M. H., Lim, S. T., 2008. Prognostic factors in patients with diffuse large B cell lymphoma : before and after the introduction of rituximab. Leukemia and Lymphoma, 49 (3), pp. 462-469
- Lim, S. T., Hee, Siew Wan, Quek, R., Lim, L. C., Yap, S. P., Loong, E. L., Sng, I., Tan, L. H. C., Ang, M. K., Ngeow, J., Tham, C. K., Ngo, L., Tan, M. H., Tao, M., 2008. Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma : significant differences in clinical characteristics and prognosis. European Journal of Haematology, 80 (1), pp. 55-60
- Toh, C. K., Hee, Siew Wan, Lim, W. T., Leong, S. S., Fong, K. W., Yap, S. P., Hsu, A. A. L., Eng, P., Koong, H. N., Agasthian, T., Tan, E. H., 2007. Survival of small-cell lung cancer and its determinants of outcome in Singapore. Annals of the Academy of Medicine Singapore, 36 (3), pp. 181-188
- Khor, T. H., Tuan, J. K. L., Hee, Siew Wan, Tham, I. W. K., 2007. Radical radiotherapy with high-dose-rate brachytherapy for uterine cervix cancer long-term results. Australasian Radiology, 51 (6), pp. 570-577
- Quek, R., Ty, A., Lim, S. T., See, S. J., Wong, M. C., Yap, S. P., Sng, I., Hee, Siew Wan, Tao, M., 2006. Primary central nervous system lymphoma in an Asian population : a 15-year experience. Oncology Research and Treatment, 29 (10), pp. 455-459
- Teo, Melissa, Tan, Yu-Meng, Chung, Alex Y, Chow, Pierce K, Cheow, Peng C, Soo, Khee-Chee, Hee, Siew Wan, Ooi, London, 2006. Metastectomy for non-colorectal, non-neuroendocrine liver secondaries. ANZ Journal of Surgery, 76 (7), pp. 575-578
- Mistry, D., Hee, S. W., Eldridge, S., Underwood, M., 2019. Chronic Headache Education and Self-management Study (CHESS) : Statistical Analysis Plan [v1.1]. University of Warwick ; Warwick Medical School
- Patel, Shilpa, Hee, Siew Wan, Sandhu, Harbinder, Yang, Yaling, Underwood, Martin, 2014. Safety, effectiveness, and cost effectiveness of decision aids still unclear. BMJ, BMJ Publishing Group Ltd
- Hee, Siew Wan, 2012. Designing a series of clinical trials.
- Lim, S. T., Hee, Siew Wan, Quek, R., Tao, M., 2008. Performance status is the single most important prognostic factor in lymphoma patients aged greater than 75 overriding other prognostic factors such as histology. Leukemia and Lymphoma, Taylor & Francis, pp. 149-151
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Postural tachycardia syndrome Exercise (PulSE) BHF grant via Coventry University | British Heart Foundation | 01 Aug 2019 | 31 Dec 2023 |
| Research Design Service renewal 2018 | National Institute for Health Research (DoH) | 01 Oct 2018 | 30 Sep 2023 |
| RECEDE study (Reducing Colonoscopies in those without bowEl DiseasE) HS&DR Stage 2 (Stage 1 - 60439) | National Institute for Health Research (DoH) | 01 May 2020 | 31 Oct 2022 |
| NIHR RfPB 2nd stage. GARFIELD-AF in Primary Care - Optimising prediction of mortality, stroke, and major bleeding for patients with atrial fibrillation using routinely collected primary care electronic health records (Stage 1 - 58973) | National Institute for Health Research (DoH) | 01 Mar 2020 | 28 Feb 2021 |
| PGfAR Full application: Chronic Headache Educations and Self-management Study (CHESS): Resubmission | National Institute for Health Research (DoH) | 05 Jan 2015 | 31 Oct 2020 |
| EU FP7 Health Call 2013.4.2-3 (FULL Proposal): InsPiRe - Innovative Methodology for Small Populations Research | European Commission | 01 Sep 2013 | 30 Nov 2016 |