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Chemistry Andrew Clark Group

Publication in synthetic methodology

  1. Anti-Beckwith stereoselectivity in amidyl radical cyclisations: Bu3SnH-mediated 5-exo-trig acyl mode cyclisation of 2-substituted pent-4-enamide radicals. A. J. Clark, R. P. Filik, G. H. Thomas, J. Sherringham. Tetrahedron Letts., 2013, 54, 4094-4097.2.
  2. Efficient and green route to g-lactams by copper catalysed reversed atom transfer radical cyclization of a-polychloro N-allylamides, using a low load of metal (0.5 mol %). F. Bellesia, A. J. Clark, F. Felluga, A. Gennaro, A. A. Isse, F. Roncagliaa, F. Ghelfi, Advanced Synthesis and Catalysis. 2013, 355, 1649-1660.
  3. Atom Transfer Cyclization with CuSO4 / KBH4: a formal AGET process also applicable to ATRP. A. J. Clark, A. E. C Collis, D. J. Fox, L. L. Halliwell, N. James, R, K. O´Reilly, H. Parekh, A. Ross, A. B. H. Willcock, and P. Wilson. J. Org. Chem., 2012, 77, 6778-6788.
  4. Bond rotation dynamics of enamides: the effect of the acyl group and potential for chirality transfer during 5-endo trig cyclisations. A. J. Clark, D. P. Curran, J. V. Geden, N. James, P. Wilson, J. Org. Chem., 2011, 76, 4546-4551.
  5. Copper(I) Halide Mediated Tandem 1,4-Aryl Migration / Oxidative 5-Exo Amidyl Radical Cyclisation of Bromosulfonamides. Andrew J Clark, David R. Fullaway, Nicholas P. Murphy, Hemal Parekh, Synlett, 2010, 610.
  6. 1,4-Aryl migration under copper(I) atom transfer conditions. A. J. Clark, S. R. Coles, A. Collis, T. Debure, C. Guy, N.P Murphy, P. Wilson, Tetrahedron Letts., 2009, 50, 5609.
  7. Copper(I) bromide mediated 1,4-aryl migration of N-sulfonyl bromoacetamides, A. J. Clark, S. R. Coles, A. Collis, N.P Murphy, P. Wilson, Tetrahedron Letts., 2009, 50¸ 6311.
  8. Bond Rotation Dynamics of N-cycloalkenyl-N-benzyl a-haloacetamide derivatives, D. B. Guthrie, K. Damodaran, D. P. Curran, P. Wilson, A. J. Clark, J. Org. Chem., 2009, 74, 4262.
  9. Copper mediated atom transfer radical cyclisation with AIBN, A. J. Clark, P. Wilson. Tetrahedron Letts., 2008, 49¸ 4848.
  10. Regiochemistry of Copper (I)-Mediated Cyclization of Dienamides. A. J. Clark, J. V. Geden, S. Thom, P. Wilson J. Org. Chem, 2007, 72, 5923-5926.
  11. Solid-Supported Catalysts for Atom Transfer Radical Cyclizations: Assessment of Support type and Ligand Structure on Catalysts Performance in the Synthesis of Heterocycles. A. J. Clark, J. V. Geden, and S. Thom. J. Org. Chem., 2006, 71, 1471-1481.
  12. Oxidative 5-Endo Radical PolarCrossover Reactions Mediated by Ceric Ammonium Nitrate. A. J. Clark, C. P. Dell, J. V. Geden, P. Mawdsley, and J. P. McDonagh, 2003, 2063-2066.
  13. Base Mediated Reactions of N-Alkyl-O-Acyl Hydroxamic Acids: Synthesis of 2,3-Dihydro-4-Isoxazole Carboxylic Ester Derivatives. A. J. Clark, D. Patel, and M. J. Broadhurst. Tetrahedron Letters, 2003, 44, 7763-7766.
  14. Atom transfer radical cyclisation reactions mediated by copper complexes. A. J. Clark, Chem. Soc. Rev. 2002, 31, 1.5-Exo Atom Transfer Cyclisation onto Alkynes by Copper (1) Complexes.
  15. A. J. Clark, G. M. Battle and A. Bridge, Tetrahedron Lett. 2001, 42, 1999-2002.
  16. Ligand Electronic Effects on Rates of Copper Mediated Atom Transfer Radical Cyclisation and Polymerisation. A. J. Clark, G. M. Battle, D. M. Haddleton, A. M. Hemming and A. Bridge, Tetrahedron Lett. 2001, 42, 2003-6.
  17. Rearrangement of Unactivated O-acyl Hydroxamic Acid Derivatives using Phosphazene Bases. A. J. Clark, Y. S. S. Faiyz, D. Patel, and M. J. Broadhurst, Tetrahedron Lett. 2001, 42, 2007-2010.
  18. Efficient beta-Lactam Synthesis via 4-Exo Atom Transfer Radical Cyclisation using CuBr(tripyyridylamine) Complex. A. J. Clark, G. M. Battle, and A. Bridge, Tetrahedron Lett. 2001, 42, 4409-4412.
  19. Solvent Effects in Copper(I) Mediated 5-Endo Cyclisation of Secondary Bromo-enamides. A. J. Clark, C. P. Dell, and J. P. McDonagh, C. R. Acad. Sci. Ser IIc:
  20. Copper Mediated Atom Transfer Radical Cyclisations of Activated and Unactivated N-Allylhaloacetamides and N-Homoallyacetamides using Chiral and Non-chiral Copper Complexes. A. J. Clark, F. De Campo, R. J. Deeth, R. P. Filik, S. Gatard, N. H. Hunt, D. Lastecoures, G. H. Thomas, J-B. Verlhac, and H.Wongtap. J. Chem. Soc., Perkin 1. 2000, 671-680.
  21. Base Catalysed Rearrangement of N-Alkyl-O-Acyl Hydroxamic Acids: Synthesis of 2-Acyloxyamide Derivatives. A. J. Clark, Y. S. S. Al-Faiyz, M. Broadhurst, D. Patel, and J. L. Peacock. J. Chem. Soc., Perkin 1. 2000, 1117-1127.
  22. N-Alkyl-2-pyridylmethanimines as Tuneable Alternatives to Bipyridine Ligands in Copper Mediated Atom Transfer Radical Cyclisation Reactions. A. J. Clark, D. J. Duncalf, R. P. Filik, D. M. Haddleton, G. H. Thomas, and H. Wongtap, Tetrahedron Lett. 1999, 3807-3810.
  23. Stereoselectivity in Amidyl Radical Cyclisations: Alkyl Mode Cyclisations. A. J. Clark, R. J. Deeth, C. J. Samuel, and H. Wongtap, Synlett. 1999, 444-446.
  24. Tandem Cyclisations of Amidyl Radicals Derived from O-Acyl Hydroxamic Acid Derivatives. A.J. Clark, R. P. Filik, J. L. Peacock, and G. H. Thomas, Synlett. 1999, 441-443.
  25. Ligand Geometry Effects in Copper Mediated Atom Transfer Radical Cyclisations. A. J. Clark, R. F. Filik, and G. H. Thomas, Tetrahedron Lett. 1999, 4885-4889.
  26. Solid Supported Catalysts for Atom Transfer Radical Cyclisation of 2-Haloacetamides. A. J Clark, R. P Filik, D. M Haddleton, A. Radique, C. J Sanders, G. H Thomas and M. E Smith. J. Org. Chem., 1999, 64, 8954-8958.
  27. Efficient Room Temperature Copper (I) Mediated 5-endo Radical Cyclisations. A. J. Clark, C.P. Dell, J. M. Ellard, N. A. Hunt, and J. P McDonagh, Tetrahedron Lett. 1999, 8619-8622.
  28. An Amidyl Radical Cyclisation Approach Towards the Synthesis of beta-Lactams. A. J. Clark, J. L. Peacock. Tetrahedron Lett. 1998, 1265-1268.
  29. Copper Diimine complexes: the synthesis and crystal structures of [Cu(C10H14N2)2(MeOH)][BF4], [Cu(C10H14N2)2]Br, [{Cu(C10H14N2)2CuBr(m-OMe)}2(MeOH)], [{Cu(C10H20N2)2CuBr(m-OMe)}2]. D. M. Haddleton, A. J. Clark, D. D. Duncalf, A. M. Heming, D. Kukulj, A. J. Shooter, J. Chem. Soc., Dalton Trans, 1998, 381-385.
  30. Atom transfer polymerisation of methyl methacrylate: Use of chiral aryl /alkyl pyridylmethanamine ligands; with copper (I) bromide and as structurally characterised chiral copper (I) complexes. D. M. Haddleton, D. D. Duncalf, D. Kukulj, A. M. Heming , A. J. Shooter, A. J. Clark, J. Materials Chem. 1998,(8)7, 1525.
  31. Stereoselectivity in amidyl radical cyclisations. Acyl mode cyclisations. A. J. Clark, J. L. Peacock, Tetrahedron Lett. 1998, 6029-6032.First structurally authenticated inorganic polymers of CuBr and CuI containing chiral bidentate N-donor 1ligands. Use of Schiff base 2,2’-bis[(4S)-4-benzyl-2-oxazoline] as Ligand. D. M. Haddleton, D. D. Duncalf, A. J. Clark, M. C. Crossman, D. Kukulj. New J. Chem. 1998, 315-317.
  32. [N-Alkyl-(2-pyridyl)methanimine]copper(I) Complexes: Characterisation and Application as Catalysts for Atom-Transfer Polymerisation. D. M. Haddleton, D. J. Duncalf, D. Kukulj, M. C. Crossman, S. G. Jackson, S. A. F. Bon, A. J. Clark, A. J. Shooter, Eur. J. Inorg. Chem. 1998, 1799-1806.
  33. Stereochemistry of amidyl radical cyclisations. A. J. Clark, R. P. Filik, G. H. Thomas, J. L. Peacock, and H. Wongtap. Abstracts of Papers Of the American Chemical Society. 1998, 216, 629.
  34. Atom transfer radical polymerisation (ATRP) of methyl methacrylate in the presence of radical inhibitors. A. J. Clark, M. C. Crossman, D. J. Duncalf, D. M. Haddleton, S. R. Morsley, A. J. Shooter, J. Chem. Soc., Chem. Commun. 1997, 1734-1735.
  35. Formation of 2-styryl heterocycles by addition of alpha-heteroradicals to unsaturated sulphimides. A. J. Clark, S. Rooke, T. Sparey, P. C. Taylor. Tetrahedron. Lett. 1996, 909-913.
  36. Cobalt salen complexes, A. Clark, and G. Pattenden, "Encyclopedia of Organic Reagents", Pergamon, October 1995.
  37. 1 pageCobalt salophen complexes, A. Clark, and G. Pattenden, "Encyclopedia of Organic Reagents", Pergamon, October 1995. 1 page
  38. Methylcobalt (DMGH)2 complex, A. Clark, G. Pattenden, B. Giese, and O. Hartung "Encyclopedia of Organic Reagents", Pergamon, October 1995. 3 pages
  39. The Formation of One or More CC bond(s) by Addition: Addition of Carbon Centered Radicals and Electrocyclic Additions to CC-Multiple bonds Chapter 1.08. A. Clark, and P. Taylor, "Organic Functional Group Transformations". Pergamon. 1995. 319-376.
  40. Cobalt (II) Chloride-Grignard reagent: an alternative to tin hydride in aryl radical cyclisations. A. J. Clark, D.I. Davies, K. Jones, C. Millbanks, J. Chem. Soc., Chem. Commun. 1994, 41-42.
  41. Cobalt-mediated Aryl radical cyclisations: A formal total synthesis of Physovenine. A. Clark, K. Jones. Tetrahedron. 1992, 48, 6875-6881.
  42. Aryl radical cyclisations, quinoline, isoquinoline, and 1-benzazepin-2-one rings via 6-and 7-exo cyclisations. A. J. Clark, K. Jones, C. McCarthy, J. M. D. Storey, Tetrahedron Lett. 1991, 32, 2829-2832.
  43. Evidence on the nature of cobalt-mediated aryl radical cyclisations. A. J. Clark, K. Jones. Tetrahedron Lett. 1989, 30, 5485-5488.