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School of Life Sciences

Fullam lab

  • Tuberculosis research at Warwick

    We are a research group working at the interface of chemistry and biology, focused on understanding how Mycobacterium tuberculosis obtains and uses nutrients to survive. We are using our knowledge to develop new strategies to kill and/or detect TB.

  • TB containment level-3 facility

    All of our TB work is undertaken in our dedicated CL3 facility.

  • Imaging mycobacteria

    We use a range of approaches to unravel how Mycobacterium tuberculosis uses and obtains sugars to survive.

  • New Containment level-3 facility.

    We will be moving our TB work into this new £1.8 million facility soon!

  • Collette receiving her Buchanan award

    Dr Collette Guy was awarded the Buchanan Memorial Award for her talk 'Killing TB from the outside by glycan targeting' at the 2022 RSC Carbohydrate meeting held in Belfast. Congratulations Collette!

Research

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death world-wide from a bacterial pathogen, with ~1.6 million deaths from TB infection and ~10 million new TB cases reported in 2021.

The broad aim of our research group is to use a multidisciplinary approach, using chemistry, biochemistry and microbiology techniques, to decipher which nutrients Mtb can access and use, the mechanisms of import and how Mtb modifies its biology and ability to cause infection when its access to nutrients is altered. We envisage that unravelling what Mtb eats will reveal new mechanisms that can be targeted in the quest for novel strategies and interventions to thwart this deadly disease and improve human health.

News

24th January 2023

Chelsea's work investigating the 'Supramolecular organization and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane' is now published in PNAS

25th November 2022

Chelsea Brown is awarded a presentation prize for her work modelling TB lipids at the Young Modellers Forum. Congratulations Chelsea!

24th November 2022

Dr Collette Guy is awarded the Buchanan memorial prize for her talk at the 2022 RSC Carbohydrate meeting on 'Killing TB from the outside by glycan targeting'. Congratulations Collette! Read our paper on tuning multimeric boronic acids to kill TB here