Inaugurals 2011
Dimitri Grammatopoulos
Date: 17 May 2011 Location: Medical Teaching Time: 6pm until 7pm, followed by a drinks reception RSVP: Register here See: Staff profile page |
Hormones (of stress), Heptahelical (proteins), Homeostatic (pathways) and other Greek words ...Species survival depends on their ability to maintain homeostasis when challenged by exogenous or endogenous stressors. Corticotropin releasing hormone (CRH), the hypothalamic peptide hormone that activates the HPA axis, plays a protagonistic role in these responses, acting as a master-switch to orchestrate and finely-tune a plethora of adaptive mechanisms. Uncovering how CRH controls cellular functions in human pathophysiology and the mechanisms cells employ to control the magnitude of responses has been Dimitris’ research interest for more than 20 years. In this talk, Dimitris will describe some of his cathartic personal experiences searching the labyrinth of cellular signals, highlight encounters with gatekeepers of cell fate, enigmatic double-faced proteins, and “rogue” cellular messengers that shape up the final destination of signals across cells and explain how this information can be translated to enable us to better understand the pathophysiology of metabolic and reproductive disorders |
