Projects for 2018 entry
Project 1: Integrated platform for hybrid modelling of taste receptor signalling
| Project supervisors | Judith Klein-Seetharaman (Warwick) and Peter J Bond (Singapore) |
| Research area | Molecular Cell Biology |
| Key aims by year |
Warwick, Year 1: Understand similarities and differences of different sweeteners and sweetness modifiers' interaction with receptors. Warwick, Year 1: Understand the effects mutations have on these interactions. Singapore, Year 2: Use multi-scale modeling approaches to assemble the repertoire of taste receptors within membranes. Singapore, Year 3: To analyze dynamics possibly associated with (allosteric) signalling; to investigate if the dynamics can be tuned in order to be reproducible at coarse-grained resolution. Warwick, Year 4: Write up thesis and manuscript. |
| Techniques |
|
Project 2: Understanding host-microbiome interactions and their impact on pathogen colonisation
| Project supervisors | Meera Unnikrishnan (Warwick) and Niranjan Nagarajan (Singapore) |
| Research area | Microbiology |
| Key aims by year |
Warwick, Year 1: Study the transcriptomic changes occurring over time in this commensal community in a co-culture gut model with selected representative bacterial species. Warwick and Singapore, Years 1 - 3: Study the responses of this community to C. difficule colonisation. Singapore, Years 3-4: Develop methods for modeling microbial dynamics in response to pathogen colonisation. Warwick, Year 4: Write up thesis and manuscript. |
| Techniques |
|